How often should I apply it for the best effect on chronically dry, rough hands?

Hand skin loses lipids and natural moisturizing factors each time it contacts water, soap, sanitizer, or cold air. The product description recommends three anchor moments: after washing, before outdoor exposure, and in the evening. In practice, keep a tube at the kitchen sink, in your bag, and on the nightstand. A pea-sized amount per hand is enough — rub until absorbed (it sinks in fast). If you wash your hands 8–10 times a day, reapplying each time prevents the cycle of re-drying. Overnight is the longest uninterrupted repair window; a slightly thicker layer before sleep lets dexpanthenol work while transepidermal water loss is lowest. You don't need to wear cotton gloves, but they can help if your sheets are a concern.