When during the day should I apply this cream for the best results?

The product is designed for "moments when hands need extra moisture during the day." The most effective routine ties application to the events that strip moisture: immediately after washing with soap (pat hands dry, leave them slightly damp, then apply), after alcohol-based sanitiser has fully evaporated, and after coming in from cold, windy weather. In office environments with forced-air heating or air conditioning, a mid-morning and mid-afternoon application helps counteract the constant low-humidity draw on the skin. Because the texture is described as a "cosmetic, smoothing texture" rather than a rich ointment, it absorbs in 30–60 seconds and leaves no residue on keyboards or fabrics, so you can reapply without interrupting work. Keep the 45 ml tube at your desk, in a bag pocket, or by the sink at home — wherever the trigger moments happen. There is no need to wait a specific interval between applications; the dual HA complex and the emollient oils (evening primrose, argan) re-form their surface film each time.

At night, a slightly thicker layer before bed works well if you sleep in a dry room, but the cream is not an overnight occlusion mask — it will absorb fully within minutes.