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Because D3 and K2 are fat-soluble vitamins, how well they are absorbed depends directly on the presence of fat in your food. Taking the tablets on an empty stomach or with just water is not the best option: without fat, the vitamins are absorbed less well. Ideally, take them with a meal or straight after one, as long as the meal contains at least a little fat: eggs, nuts, avocado, vegetable oil or butter, oily fish, dairy products.
The time of day does not really matter, but many people prefer to take fat-soluble vitamins in the first half of the day — with breakfast or lunch. It simply fits more easily into a daily routine and reduces the risk of forgetting.
You should also take into account your total vitamin D intake from all sources: if you are already taking other supplements containing D3 or multivitamins, the combined amount should not exceed what is right for you. If in doubt, it is sensible to have your blood vitamin D level checked and to consult a specialist — especially if you have chronic conditions or take medication.