Methyl salicylate is chemically related to aspirin; individuals who react to salicylates (for example, with asthma exacerbation, urticaria, or gastrointestinal irritation after oral NSAIDs) can experience systemic absorption through the skin, especially if large areas are treated or the skin barrier is compromised. Levomenthol can trigger contact dermatitis or a strong burning sensation on very sensitive or atopic skin. The manufacturer explicitly advises against use on damaged, inflamed, or broken skin and on mucous membranes. For children under 12, during pregnancy, or while breastfeeding, there is insufficient safety data for topical salicylate/menthol combinations at this concentration, so a pharmacist or physician should assess the risk-benefit balance. If you take anticoagulants, have a bleeding disorder, or are scheduled for surgery, mention the product to your clinician because salicylates can theoretically affect platelet function even with dermal exposure. Store the tube below 25 °C, cap tightly after each use, and discard 12 months after first opening — the base can oxidize and the actives degrade, altering both efficacy and irritation potential.