Dimexid's key feature is its ability to temporarily increase skin permeability, acting as a "carrier" to help accompanying ingredients pass through the skin barrier more easily. This makes the choice of what you mix with it critically important. You should only combine it with products whose ingredients you trust and fully understand. Avoid mixing it with substances that are not intended for deep skin penetration, products containing high concentrations of potentially irritating actives (like strong acids or retinoids unless you are experienced with them), or any medication or compound not explicitly approved for topical use with a penetration enhancer. The increased absorption could intensify both the effects and potential side effects of the combined ingredients.
It is not a standalone product but an auxiliary solution. Its role is to enhance the effect of masks, compresses, or other local skin procedures. Therefore, consider the purpose of the entire mixture. If you are using it for a warming compress or recovery-focused procedure, ensure the other components are suitable for that goal. A patch test with the final, diluted mixture is a sensible first step to assess compatibility. If you are pregnant, breastfeeding, have reactive skin, or are using any medications, consult a specialist before use.