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Berberine belongs to the active plant alkaloids: it takes part in cellular signalling processes related to the use of glucose and fats. This biological activity is what makes it interesting as a supplement, and at the same time it calls for care when it is taken together with medicines.
Particular caution is recommended for those who already take medicines that affect carbohydrate or lipid metabolism, as well as any products with a narrow therapeutic window. In such cases it is better to discuss taking the supplement and the medicine together with your doctor in advance, not because berberine is known to be dangerous, but because a specialist can assess the specific situation in light of your treatment plan and current test results.
This is especially relevant if you regularly have laboratory tests and track how the values change: the doctor can adjust monitoring to take the added supplement into account.
During pregnancy and breastfeeding this product must not be taken, as stated on the label; the supplement is intended for adults only.