If you are already using strong exfoliating acids, retinoids, or similar active skincare, do not change several things at once. The product description specifically advises introducing new skincare one step at a time, so your skin has a chance to show how it reacts. If you are just starting this cream, use it alone for a few days before starting or changing an acid or retinoid product.
In a routine with actives, a common order is: cleanse, apply water-based serums or leave-on exfoliants, then finish with a moisturiser. This cream can be the final moisturising layer in that sequence. Wait a few minutes after applying acids or retinoids so your skin is dry, then apply a small amount of the cream. This does not stop the effects of the active product, but it can help your skin feel more comfortable while you adjust.
Avoid the eye area, and remember that the formula contains perfume. If your skin is already sensitive from retinoids or acids, the perfume may be too much, so test on a small area first. If you notice stinging, redness, or peeling beyond what your active product usually causes, take a break from either the cream or the active until your skin settles.
The cream can be used morning and evening, but on nights when you use a strong resurfacing product, it often makes sense to keep the routine simple: cleanser, moisturiser, and nothing else. This cream is meant for hydration and comfort, not for treating irritation, so if a reaction develops, stop use and consult a specialist if needed.