Yes, you can use both, but timing and care are important. Frequent use of alcohol-based hand sanitisers can be drying to both skin and nails. The moisturising agents in this pen (like pentylene glycol, glycerin, and propylene glycol) can help counterbalance some of that dryness by maintaining moisture on the nail surface and cuticle. For best results, apply the pen to clean, dry nails. If your hands are damp from sanitiser, wait a minute for them to dry completely first. Consider incorporating the pen into your routine after washing and drying your hands thoroughly, or at a separate time like in the evening. This allows the product to form its film without being immediately washed or rubbed off. It is part of a maintenance routine, not a substitute for a balanced diet or medical advice if you have persistent concerns.