For the most noticeable difference, use the cream consistently rather than occasionally. Start by washing your feet, ideally with a warm foot bath, because warm water makes thickened skin softer and helps urea spread more evenly. Dry your feet thoroughly, then apply a thin layer only to rough, intact areas such as the heels and the outer edge of the soles. Massage it in gently until absorbed; the formula is fast-absorbing, so you do not need to apply a thick coat.
Once a day is a reasonable starting point, and many people prefer to do this in the evening so that the product can work overnight without being rubbed off by shoes and socks. You can continue using it as part of your normal foot-care routine, not only when the skin already feels hard. If your skin is very thick, daily use for several weeks is usually needed before the surface becomes noticeably smoother. The effect is gradual because the cream helps loosen built-up cells over time rather than removing them immediately.
Do not apply this product to cracked, irritated, or otherwise damaged skin, and avoid the eye area and mucous membranes. If you have sensitive skin, do a patch test on a small area first. If redness, stinging, or any other irritation appears, stop using it and consult a pharmacist or doctor before continuing. Keep the tube closed after use, store it at room temperature, and wash your hands after applying so you do not accidentally transfer the cream to sensitive areas.
Using this cream after a foot bath and following with a cotton sock is a common way to increase comfort. There is no need to combine it with strong exfoliating tools at the same time; the urea itself already helps loosen dead cells, and additional friction can easily irritate skin that is being softened.